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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K3
All Species:
18.48
Human Site:
S249
Identified Species:
33.89
UniProt:
P46734
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46734
NP_002747.2
347
39318
S249
Q
K
G
Y
N
V
K
S
D
V
W
S
L
G
I
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
E285
Q
V
E
G
D
A
A
E
T
P
P
R
P
R
T
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546666
347
39324
S249
Q
K
G
Y
N
V
K
S
D
V
W
S
L
G
I
Cat
Felis silvestris
Mouse
Mus musculus
O09110
347
39278
S249
Q
K
G
Y
N
V
K
S
D
V
W
S
L
G
I
Rat
Rattus norvegicus
Q4KSH7
419
47517
A303
K
P
D
Y
D
I
R
A
D
V
W
S
L
G
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
S254
Q
K
G
Y
N
V
K
S
D
V
W
S
L
G
I
Chicken
Gallus gallus
Q90891
398
44059
S291
G
A
E
G
E
S
H
S
V
S
P
W
A
R
P
Frog
Xenopus laevis
Q07192
446
50082
S335
R
Q
G
Y
D
V
R
S
D
V
W
S
L
G
I
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
N262
E
T
N
Q
K
G
Y
N
V
K
S
D
I
W
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
G237
R
S
D
V
W
S
L
G
I
G
M
I
E
M
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
W253
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
G255
S
S
D
I
W
S
L
G
M
S
V
L
E
C
A
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
I547
T
Y
T
V
Q
S
D
I
W
S
L
G
L
S
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
30.7
N.A.
99.1
N.A.
96.5
37.2
N.A.
89.7
30.3
42.1
75.3
N.A.
57
N.A.
37.7
N.A.
Protein Similarity:
100
47
N.A.
99.7
N.A.
98.8
56.7
N.A.
93.1
48.7
58
84.4
N.A.
72.9
N.A.
55.6
N.A.
P-Site Identity:
100
6.6
N.A.
100
N.A.
100
53.3
N.A.
100
6.6
73.3
0
N.A.
0
N.A.
0
N.A.
P-Site Similarity:
100
13.3
N.A.
100
N.A.
100
86.6
N.A.
100
6.6
100
20
N.A.
6.6
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
23.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.2
35.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
8
8
8
0
0
0
0
8
0
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
8
24
0
24
8
8
0
47
0
0
8
0
0
0
% D
% Glu:
8
0
16
0
8
0
0
8
0
0
0
0
16
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
39
16
0
8
0
16
0
8
8
8
0
47
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
8
0
8
8
0
0
16
8
0
54
% I
% Lys:
8
31
0
0
8
0
31
0
0
8
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
16
0
0
8
8
8
54
8
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
8
0
0
8
0
% M
% Asn:
0
0
8
0
31
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
8
16
0
8
0
8
% P
% Gln:
39
8
0
8
8
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
16
0
0
8
0
0
16
0
0
0
0
8
0
16
0
% R
% Ser:
8
16
0
0
8
31
0
47
8
24
8
47
0
8
8
% S
% Thr:
8
8
8
0
0
0
0
0
8
0
0
0
8
0
8
% T
% Val:
0
8
8
16
0
39
8
0
16
47
8
0
0
0
0
% V
% Trp:
0
0
0
0
16
0
0
8
8
0
47
8
0
8
0
% W
% Tyr:
8
8
0
47
0
0
8
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _